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OWEN N. WITTE, MD
Investigator, Howard Hughes Medical Institute
Professor of Microbiology, Immunology and Molecular Genetics
Professor of Molecular and Medical Pharmacology
Owen Witte received his undergraduate degree from Cornell and his MD from Stanford University. He completed postdoctoral research at MIT then joined the faculty at UCLA where he presently is an Investigator of the Howard Hughes Medical Institute, Professor of Microbiology, Immunology and Molecular Genetics where he holds the President's Chair in Developmental Immunology, and Professor of Molecular and Medical Pharmacology at the David Geffen School of Medicine at UCLA. He was named the Founding Director of the Institute of Stem Cell Biology and Medicine in 2005, recently renamed the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.
He has made significant contributions to the understanding of human leukemias, immune disorders, and epithelial cancer stem cells. His work includes the discovery of tyrosine kinase activity for the ABL gene and the demonstration of the BCR-ABL oncoproteins in human leukemias, leading to the development of kinase targeted therapy as an effective treatment for these leukemias and other cancers. His work also lead to the co-discovery of Bruton’s tyrosine kinase which is required for normal B-lymphocyte development, and when mutated leads to X-linked agammagloblulinemia, a form of immune deficiency. Recent work has concentrated on defining the stem cells for epithelial cancers of the prostate and other organ sites to help define new types of therapy for these diseases.
Dr. Witte is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and was recently elected to the Institute of Medicine. He has received recognition for his research including the Milken Foundation Award, the Rosenthal Award of the American Association for Cancer Research, the Dameshek Prize of the American Society of Hematology, the Alpert Foundation Prize, and The Leukemia and Lymphoma Society’s de Villiers International Achievement Award. Dr. Witte was the 2007 UCLA Faculty Research Lecturer. He currently serves on several editorial and advisory boards.
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